THE DIPHTHERIA TOXIN TRANSLOCATION DOMAIN IMPAIRS RECEPTOR SELECTIVITY IN CANCER CELL-TARGETED PROTEIN NANOPARTICLES

The Diphtheria Toxin Translocation Domain Impairs Receptor Selectivity in Cancer Cell-Targeted Protein Nanoparticles

Protein-based materials intended as nanostructured drugs or drug carriers are progressively gaining interest in nanomedicine, since their structure, assembly and cellular interactivity can be tailored by recruiting functional domains.The main bottleneck in the development of deliverable protein materials is the lysosomal degradation that follows en

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Construction and validation of a prediction model for fall risk in hospitalized older adults with osteoporosis

ObjectiveThe aim of this study is to develop and validate a prediction model for fall risk factors in hospitalized older adults with osteoporosis.MethodsA total of 615 older adults with osteoporosis hospitalized at a tertiary (grade 3A) hospital in Nantong City, Jiangsu Province, China, between September 2022 and August 2023 were selected for the s

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Conformal Carroll scalars with boosts

We construct two distinct actions for scalar fields that are invariant Toners under local Carroll boosts and Weyl transformations.Conformal Carroll field theories were recently argued to be related to the celestial holography description of asymptotically flat spacetimes.However, only few explicit examples of such theories are known, and they lack

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